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وبلاگ تخصصی شیمی - دانلود مقالهNano Hydroxyapatite/Collagen, Nano Hydroxyapatite and Anodic Oxides on Titanium
Nano Hydroxyapatite/Collagen, Nano Hydroxyapatite
and Anodic Oxides on Titanium
— Preparation, Characterization and Biological Responses —


تعداد صفحات:101/حجم فایل:3.21مگابیت


INTRODUCTION
Titanium is a successful biocompatible material that is extensively used for
biomedical applications, especially for bone-anchoring systems, such as dental,
orthopaedic implants and osteosynthesis applications. It has advantageous bulk
mechanical properties such as a low modulus of elasticity, a high strength-toweight
ratio, and passive surface properties i.e. excellent corrosion resistance
and low rates of ion release as well as a high degree of biocompatibility which is
largely attributed to an inert surface oxide film [45, 71].
Bone formation induced by osteoblast-like cells at the implant-tissue interface is
a complex process, involving a number of cellular functions such as cellular
adhesion, migration and proliferation followed by the expression of markers of
the osteoblast phenotype and synthesis, deposition, and mineralization of a
bone matrix. Bone-implant interaction processes are, to a great extent,
governed by surface properties of implant devices. A variety of surface
properties including physicochemical as well as surface geometrical properties
are believed to be responsible for the biological performance, i.e. cell
attachment and subsequent osseointegration, of titanium implants [3,72]. The
response of titanium to its biological surroundings is governed by ion leaching
and by corrosion with the release of particles. These processes are not only
dependent on solubility of the implant, but also on intercellular turnover, cellular
activity, bacteria, pH, and other factors. The influence of the surface is
particularly dominant during the early stages of biological response and it is also
known that the very first biochemical interactions at the implant-tissue interface
are decisive with respect to the course of later reactions and the final cell/tissue
architecture of the interface. Besides, the fixation of implants either through
chemical bonding or by mechanical locking for is determined by their surface
properties, primarily topography and surface chemistry, which directly affect the
interaction of implants and bones. Consequently, alteration of implant surfaces
to promote titanium osseointegration, a process of the direct anchorage of
implants by bone formation around the implants without any intervening soft or
fibrous tissue [68], and their biological responses have been of a great interest
in biomaterials, either from academic or industrial points of view.


تاریخ : سه شنبه 20 دی 1390 | 07:33 ق.ظ | نویسنده : علی ناطقی | نظرات
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